HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dimethylpyrrolidine → HCID 67203821, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dimethylpyrrolidine | HCID 96034 | — |
| Reactant | 4-Bromo-but-2-enoic acid[4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide | HCID 54242075 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67203821 | HCID 67203821 | — |
Reaction Steps
In the same manner as Example 117, 4-bromo-but-2-enoic acid[4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide. (0.51 mmol.) was reacted with 2,5-dimethylpyrrolidine (1.02 mmol., 101 mg.) in dimethylformamide. The crude product was also purified via chromatography as Example 117, leaving 214 mg. (82%) of the yellow product: mp 110-113° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06297258B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-34d663812b3f40c7a622a2414f8ece8b |
| Source note | uspto-grants-2001_10 |