化工社化工社 化学情報印刷レポート · 研究参考用
Diethyl Ether → Heptanoic acid, 6-oxo-, methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 6-Oxoheptanoic acid | HCID 98810 | — |
| 反応物 | 1-Methyl-2-nitro-1-nitrosoguanidine | HCID 9562060 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Heptanoic acid, 6-oxo-, methyl ester | HCID 288022 | — |
反応手順
To a rapidly stirred mixture of diethyl ether (175 ml) and 40% KOH (52 ml) at 0° C. was added MNNG (15.4 g, 105 mmol). The mixture was stirred for 10 minutes. The ethereal layer was transferred to a solution of 6-oxo-heptanoic acid 1-1 (5.0 g, 34.68 mmol) and CH2Cl2 at 0° C. The solution was purged with argon for 30 minutes and then concentrated. Flash chromatography (silica, 30% to 50% EtOAc/hexanes) gave ester 1-2 as a clear oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06297249B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-db2cf0e36f7b48698ce9156fd0af1ec5 |
| 出典メモ | uspto-grants-2001_10 |