HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 5-(1,8-naphthyridin-2-yl)pentanoate → Methyl 5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 5-(1,8-naphthyridin-2-yl)pentanoate | HCID 11447926 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Methyl 5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoate | HCID 11265157 | — |
Reaction Steps
A mixture of 1-4 (630 mg, 2.58 mmol) and 10% Pd/carbon (95 mg) in EtOH (25 mL) was stirred under a balloon of hydrogen for 72 h. Following filtration and evaporative removal of the solvent, the residue was chromatographed (silica gel, 70% ethyl acetate/hexanes) to give 1-5 as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06297249B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-39e3d5a5c77345ed9f62c445139afd32 |
| Source note | uspto-grants-2001_10 |