HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-(1,8-naphthyridin-2-yl)butanoate → Ethyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-(1,8-naphthyridin-2-yl)butanoate | HCID 10955797 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Ethyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butanoate | HCID 22594332 | — |
Reaction Steps
A solution of 2-3 (2.3 g, 9.4 mmol) in 50 mL EtOAc was treated with 10% Pd/C (230 mg) and a hydrogen balloon. After 4 days the reaction filtered through celite, concentrated, and purified by flash chromatography (silica, 70% EtOAc/hexane), providing 2-4 as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06297249B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-ab49f92bec554aecb42be294a9de3fee |
| Source note | uspto-grants-2001_10 |