HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → tert-Butyl (2-(1,8-naphthyridin-2-yl)ethyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3-Pyridinecarboxaldehyde, 2-amino- | HCID 737633 | — |
| Reactant | tert-butyl N-(3-oxobutyl)carbamate | HCID 12111481 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-Butyl (2-(1,8-naphthyridin-2-yl)ethyl)carbamate | HCID 53952251 | — |
Reaction Steps
A solution of 10-4 (10 g, 53.4 mmol), 2-amino-3-formylpyridine 1-3 (7.2 g, 64 mmol), 20% aq. KOH (1 mL), and ethanol (200 mL) was heated at reflux for 3 h. Evaporation of the solvents and flash chromatography (silica, 70 CHCl3/28 EtOAc/2 MeOH) gave 10-5 as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06297249B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-d38972e01f11444a95781bb690afaf08 |
| Source note | uspto-grants-2001_10 |