HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium bisulfate → tert-Butyl (4-oxopentyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium bisulfate | HCID 516920 | — |
| Reactant | tert-butyl N-(3-(methoxy(methyl)carbamoyl)propyl)carbamate | HCID 23112516 | — |
| Reactant | HCID 178418573 | HCID 178418573 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | tert-Butyl (4-oxopentyl)carbamate | HCID 21478928 | — |
Reaction Steps
To a stirred solution of 11-3 (10.0 g, 40.5 mmol) and THF (200 ml) at 0° C. was added methylmagnesium bromide (27.0 ml, 91.0 mmol; 3M in ether) dropwise over 20 minutes. After 2.0 hours, 10% KHSO4 was added slowly. The mixture was extracted with EtOAc. The organic portion was washed with sat. NaHCO3, brine, and dried over MgSO4. Evaporative removal of the solvent gave 11-4 as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06297249B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-77a3242b76974407ac9cf7243dffa463 |
| Source note | uspto-grants-2001_10 |