Benzoyl chloride → HCID 57559112, compound

HRID 37925Notes

Reaction equation

HRID 37925 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:7]3[CH2:16][CH2:15][NH:14][CH:13]=[C:12]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:8]=3[NH:9][C:10]=2[CH:11]=1.[C:22](Cl)(=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:22]([N:14]1[CH2:15][CH2:16][C:7]2[C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:11][C:10]=3[NH:9][C:8]=2[C:12]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13]1)(=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 66640827Ethyl 8-methoxy-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate

Product 1

HCID 57559112HCID 57559112, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 2A by using ethyl 8-methoxy-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate and benzoyl chloride; 1H-NMR (CDCl3): δ 10.41 (1H, br s), 7.98 (1H, s), 7.56 (2H, m), 7.52 (1H, m), 7.46 (2H, m), 7.39 (1H, d), 6.86 (1H, d), 6.79 (1H, dd), 4.22 (2H, q), 4.19 (2H, t), 3.86 (3H, s), 3.23 (2H, t), 1.20 (3H, t); MS (ES): 391 (MH+).

Sources & evidence

ORD record
ord-d0eef79692c2458b9dd75917d36538c2
Source dataset
uspto-grants-2013_09
Patent number
US08524704B2

Reaction notes

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