Benzoyl chloride → HCID 57559158, compound

HRID 37926Notes

Reaction equation

HRID 37926 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[CH2:15][CH2:14][NH:13][CH:12]=[C:11]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:7]=3[NH:8][C:9]=2[CH:10]=1.[C:21](Cl)(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[CH2:15][CH2:14][N:13]([C:21](=[O:28])[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH:12]=[C:11]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:7]=3[NH:8][C:9]=2[CH:10]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 66639977Ethyl 8-fluoro-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate

Product 1

HCID 57559158HCID 57559158, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 2A by using ethyl 8-fluoro-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate and benzoyl chloride; 1H-NMR (CDCl3): δ 10.57 (1H, br s), 8.05 (1H, s), 7.55 (3H, m), 7.45 (3H, m), 7.05 (1H, dd), 6.87 (1H, m), 4.22 (4H, m), 3.24 (2H, t), 1.2 (3H, t); MS (ES): 379 (MH+).

Sources & evidence

ORD record
ord-bb05c20c07b74a13b2186a8b17f0091a
Source dataset
uspto-grants-2013_09
Patent number
US08524704B2

Reaction notes

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