Acetyl chloride → HCID 57559131, compound

HRID 37927Notes

Reaction equation

HRID 37927 reaction equation
[CH3:1][C:2]1[C:10]2[NH:9][C:8]3[C:11]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:12][NH:13][CH2:14][CH2:15][C:7]=3[C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:21](Cl)(=[O:23])[CH3:22]>>[C:21]([N:13]1[CH2:14][CH2:15][C:7]2[C:6]3[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[C:10]=3[NH:9][C:8]=2[C:11]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:12]1)(=[O:23])[CH3:22]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 66640813Ethyl 7-methyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate

Product 1

HCID 57559131HCID 57559131, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 2A using ethyl 7-methyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate and acetyl chloride; 1H-NMR (CDCl3): δ 10.50 (1H, br s), 8.12 (1H, br s), 7.36 (1H, d), 7.01 (2H, m), 4.39 (2H, q), 4.01 (2H, m), 3.16 (2H, m), 2.53 (3H, s), 2.39 (3H, s), 1.43 (3H, t); MS (ES): 313 (MH+).

Sources & evidence

ORD record
ord-e160dc29909e4ac19b031981fb231edd
Source dataset
uspto-grants-2013_09
Patent number
US08524704B2

Reaction notes

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