Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | 3-Pyridinecarboxaldehyde, 2-amino- | HCID 737633 | — |
| Reactant | HCID 54440811 | HCID 54440811 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 53827885 | HCID 53827885 | — |
Reaction Steps
A mixture of 28-3 (4.1 g, 18.3 mmol), proline (2.7 g, 23.8 mmol), and 1-3 (2.9 g, 23.8 mmol ) in 50 mL EtOH was heated at 110° C. for 24 hr. The reaction mixture was concentrated and purified by silica gel chromatography (EtOAc, 100%) to afford the desired product 28-4 as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06297249B1 |
|---|
| Source dataset | uspto-grants-2001_10 |
|---|
| ORD ID | ord-e1559f699e364314a53ec9bf1cd3ced4 |
|---|
| Source note | uspto-grants-2001_10 |
|---|
