HCID 20691579, compound → HCID 54211117, compound

HRID 379275Notes

Reaction equation

HRID 379275 reaction equation
[CH3:1][O:2][C:3](=[O:20])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[N:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1.[H][H]>[Pd].C(O)C>[CH3:1][O:2][C:3](=[O:20])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[CH2:16][CH2:15][CH2:14][NH:13][C:12]=2[N:11]=1

Participants

5

Reactant 2

HCID 20691579HCID 20691579, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54211117HCID 54211117, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent2×

Procedure

To a stirred suspension of 10% palladium on carbon (600 mg) in ethanol (25 mL) was added a solution of 7-[1,8]naphthyridin-2-yl-heptanoic acid methyl ester 29-3 (3.6 g) in ethanol (75 mL) and the mixture was subjected to an atmosphere of hydrogen for 18 hours. The reaction mixture was filtered through Celite and concentrated at reduced pressure to give 29-4 as an oil.

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationconcentrated at reduced pressure

Sources & evidence

ORD record
ord-b9e2ec9d504249f2a003f77aa92fd3c2
Source dataset
uspto-grants-2001_10
Patent number
US06297249B1

Reaction notes

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