4-Fluorobenzoyl chloride → HCID 57559142, compound

HRID 37937Notes

Reaction equation

HRID 37937 reaction equation
[CH2:1]([NH:3][C:4]([CH:6]1[NH:19][CH:18]=[C:17]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:9]2[NH:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:8]=2[CH2:7]1)=[O:5])[CH3:2].[F:25][C:26]1[CH:34]=[CH:33][C:29]([C:30](Cl)=[O:31])=[CH:28][CH:27]=1>>[CH2:1]([NH:3][C:4]([CH:6]1[N:19]([C:30](=[O:31])[C:29]2[CH:33]=[CH:34][C:26]([F:25])=[CH:27][CH:28]=2)[CH:18]=[C:17]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:9]2[NH:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:8]=2[CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 66640651Ethyl 2-ethylcarbamoyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate

Product 1

HCID 57559142HCID 57559142, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 2A by using ethyl 2-ethylcarbamoyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate and 4-fluorobenzoyl chloride; 1H-NMR (CDCl3): δ 10.21 (1H, br s), 8.27 (1H, s), 7.71-7.79 (3H, m), 7.53 (1H, m), 7.36 (1H, d), 7.20 (1H, m), 7.11 (2H, m), 6.11 (1H, d), 5.32 (1H, t), 4.21 (2H, m), 3.87 (1H, dd), 3.20 (1H, dd), 2.86-3.06 (2H, m), 1.18 (3H, t), 0.57 (3H, t); MS (ES): 450 (MH+).

Sources & evidence

ORD record
ord-e5542fd990d745638358dfeb5b187192
Source dataset
uspto-grants-2013_09
Patent number
US08524704B2

Reaction notes

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