反应详情

温度

80 °C

A mixture of 3.50 g (9.0 mmol) N-(4-iodo-6-morpholin-4-yl-pyridin-3-yl)-2,2-dimethyl-propionamide, 35 ml toluene, 18 ml 2 N sodium carbonate solution, 312 mg (0.27 mmol) tetrakis(triphenylphosphine)palladium(0) and 1.34 g (9.9 mmol) o-tolylboronic acid was heated under argon at 80° C. for 12 h. After cooling to room temperature, the aqueous phase was separated and washed twice with ethyl acetate. The combined organic layers were washed with 50 ml brine, dried (sodium sulfate) and evaporated. Purification by flash-chromatography gave 3.23 g (quantitative) of the title compound as a white foam.

1. temperatureAfter cooling to room temperature
2. customthe aqueous phase was separated
3. washwashed twice with ethyl acetate
4. washThe combined organic layers were washed with 50 ml brine
5. dry with materialdried (sodium sulfate)
6. customevaporated
7. customPurification by flash-chromatography