HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 379422Generated: October 27, 2026
Water → N-benzyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide
https://huagongshe.com/reaction/379422
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | N-benzyl-6-chloro-4-o-tolyl-nicotinamide | HCID 12167314 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | N-benzyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide | HCID 12167316 | 100% |
Reaction Steps
A mixture of 5.0 g (14.8 mMol) of N-benzyl-6-chloro-4-o-tolyl-nicotinamide and 25 ml morpholine was heated to 100° C. for 3.5 hours. After cooling to room temperature, extractive work-up with ethyl acetate, water and brine gave 5.7 g (100%) N-benzyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide as a yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06297375B1 |
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| Source dataset | uspto-grants-2001_10 |
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| ORD ID | ord-f3d164ad593f4a6891208544ae1ceb8d |
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| Source note | uspto-grants-2001_10 |
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