Azacyclonol → N-Methyl-N-(4-(4-(hydroxydiphenylmethyl)-piperidin-1-yl)-2-phenylbutyl)benzamide

HRID 379449Notes

Reaction equation

HRID 379449 reaction equation
[CH3:1][N:2]([CH2:11][CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:13][CH2:14]S(C)(=O)=O)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[OH:25][C:26]([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[CH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[CH3:1][N:2]([CH2:11][CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:13][CH2:14][N:30]1[CH2:31][CH2:32][CH:27]([C:26]([OH:25])([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[CH2:28][CH2:29]1)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 15723AzacyclonolHCID 18354437N-methyl-N-(2-phenyl-4-methanesulfonylbutyl)benzamide

Product 1

HCID 15870532N-Methyl-N-(4-(4-(hydroxydiphenylmethyl)-piperidin-1-yl)-2-phenylbutyl)benzamide

Procedure

Prepare by the method of Example 1.7 using N-methyl-N-(2-phenyl-4-methanesulfonylbutyl)benzamide and 4-(hydroxydiphenylmethyl)piperidine to give the title compound.

Sources & evidence

ORD record
ord-1b2bab0e5f8145279edc6d62e10d48ef
Source dataset
uspto-grants-2001_10
Patent number
US06297259B1

Reaction notes

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