4-(1-(4-fluorobenzyl)-1H-benzimidazole-2-carbonyl)piperidine → N-Methyl-N-(4-(4-(1-(4-fluorobenzyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-(benzo[1.3]dioxol-5-yl)butyl)benzamide

HRID 379451Notes

Reaction equation

HRID 379451 reaction equation
[CH3:1][N:2]([CH2:11][CH:12]([C:19]1[CH:27]=[CH:26][C:22]2[O:23][CH2:24][O:25][C:21]=2[CH:20]=1)[CH2:13][CH2:14]S(C)(=O)=O)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[F:28][C:29]1[CH:52]=[CH:51][C:32]([CH2:33][N:34]2[C:38]3[CH:39]=[CH:40][CH:41]=[CH:42][C:37]=3[N:36]=[C:35]2[C:43]([CH:45]2[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]2)=[O:44])=[CH:31][CH:30]=1>>[CH3:1][N:2]([CH2:11][CH:12]([C:19]1[CH:27]=[CH:26][C:22]2[O:23][CH2:24][O:25][C:21]=2[CH:20]=1)[CH2:13][CH2:14][N:48]1[CH2:49][CH2:50][CH:45]([C:43]([C:35]2[N:34]([CH2:33][C:32]3[CH:31]=[CH:30][C:29]([F:28])=[CH:52][CH:51]=3)[C:38]3[CH:39]=[CH:40][CH:41]=[CH:42][C:37]=3[N:36]=2)=[O:44])[CH2:46][CH2:47]1)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 155428834-(1-(4-fluorobenzyl)-1H-benzimidazole-2-carbonyl)piperidineHCID 21697511N-methyl-N-(2-(benzo[1,3]dioxol-5-yl)-4-methanesulfonylbutyl)benzamide

Product 1

HCID 10189708N-Methyl-N-(4-(4-(1-(4-fluorobenzyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-(benzo[1.3]dioxol-5-yl)butyl)benzamide

Procedure

Prepare by the method of Example 1.7 using N-methyl-N-(2-(benzo[1,3]dioxol-5-yl)-4-methanesulfonylbutyl)benzamide and 4-(1-(4-fluorobenzyl)-1H-benzimidazole-2-carbonyl)piperidine to give the title compound.

Sources & evidence

ORD record
ord-91d44a6f6160484b95bfd236cf885238
Source dataset
uspto-grants-2001_10
Patent number
US06297259B1

Reaction notes

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