N-methyl-N-(2-phenyl-4-methanesulfonylbutyl)benzamide → N-Methyl-N-(4-(4-(1-(2-(3.3-dimethylallyloxy)ethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide

HRID 379468Notes

Reaction equation

HRID 379468 reaction equation
[CH3:1][N:2]([CH2:11][CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:13][CH2:14]S(C)(=O)=O)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:25][C:26]([CH3:49])=[CH:27][CH2:28][O:29][CH2:30][CH2:31][N:32]1[C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=2[N:34]=[C:33]1[C:41]([CH:43]1[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]1)=[O:42]>>[CH3:1][N:2]([CH2:11][CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:13][CH2:14][N:46]1[CH2:47][CH2:48][CH:43]([C:41]([C:33]2[N:32]([CH2:31][CH2:30][O:29][CH2:28][CH:27]=[C:26]([CH3:49])[CH3:25])[C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=3[N:34]=2)=[O:42])[CH2:44][CH2:45]1)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 18354437N-methyl-N-(2-phenyl-4-methanesulfonylbutyl)benzamideHCID 216974184-(1-(2-(3,3-dimethylallyloxy)ethyl)-1H-benzimidazole-2-carbonyl)piperidine

Product 1

HCID 21697367N-Methyl-N-(4-(4-(1-(2-(3.3-dimethylallyloxy)ethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide

Procedure

Prepare by the method of Example 1.7 using N-methyl-N-(2-phenyl-4-methanesulfonylbutyl)benzamide and 4-(1-(2-(3,3-dimethylallyloxy)ethyl)-1H-benzimidazole-2-carbonyl)piperidine to give the title compound.

Sources & evidence

ORD record
ord-f485ccad889c4dfd8ff9b2f82c5c05f8
Source dataset
uspto-grants-2001_10
Patent number
US06297259B1

Reaction notes

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