反应详情

Alternately, combine methyl 2-methoxy-5-(1H-tetrazol-1-yl)benzoate (13.3 g, 56.8 mmol) and methanol (150 mL). Add 1M aqueous solution of sodium hydroxide (62.5 mL, 62.5 inmol). Heat to reflux. After 30 minutes, add methanol (50 mL) and water (50 mL) and continue the heat at reflux. After 1 hour, concentrate mvacuo to remove most of the solvent. Adjust the pH to about 1 to 2 using a 1M aqueous hydrochloric acid solution to give a solid. Collect the solid by filtration, rinse with water, and dry to give 2-methoxy-5-(1H-tetrazol-1-yl)benzoic acid.

1. temperatureHeat to reflux
2. temperatureheat
3. temperatureat reflux
4. waitAfter 1 hour
5. concentrationconcentrate mvacuo
6. customto remove most of the solvent
7. customto give a solid
8. customCollect the solid
9. filtrationby filtration
10. washrinse with water
11. customdry