HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2-Methoxy-5-(trifluoromethoxy)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-methoxy-5-(trifluoromethoxy)benzoic Acid | HCID 2775286 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Methoxy-5-(trifluoromethoxy)benzoyl chloride | HCID 3580596 | — |
Reaction Steps
Combine 2-methoxy-5-trifluoromethoxybenzoic acid (0.6 g, 2.53 mmol) and dichloromethane (10 mL). Cool in an ice bath. Add dropwise oxalyl chloride (0.64 mL, 5.0 mmol) followed by dimethylformamide (1 drop). Warm to ambient temperature. After 3 hours, evaporate invcuo and dry to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06297259B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-4614e54603334fb88f3ec6fd29f4d154 |
| Source note | uspto-grants-2001_10 |