Hydrazine → HCID 15884729, compound

Participants

Reaction Steps

To a solution of 2-methoxymethyl-5-(2-methoxyphenyl)-(2-phthalimidoethyl)-tetrahydropyrrole (333 mg, 0.85 mmol) in ethanol (5 mL) was added anhydrous hydrazine (80 μl, 2.5 mmol). The resulting suspension was stirred at room temperature for 3 days. The reaction mixture was filtered through Celite™, and the solid was washed with methanol (40 mL). The filtrate was concentrated in vacuo, the residue was triturated with CH2Cl2 (40 mL) and filtered to remove any remaining byproduct. The filtrated was again concentrated to afford the title compound as a light yellow oil (211 mg). MS m/z: 265 (M+H).

Provenance & Evidence