Methanol → HCID 18366518, compound

Participants

Reaction Steps

To a solution of N-benzyl-2,3-dihydro-2-(2-methoxyphenyl)-4-pyridone (5.5 g, 18.77 mmol) (which was prepared by the procedures of Yamamoto et al., Tetrahedron, 1993, 49, 1749) in methanol (80 mL) was added Pd(OH)2 (1.7 g) and the resulting suspension was hydrogenated (50 psi) for 20 hours. Pd-C was then filtered off and the crude reaction mixture was concentrated in vacuo to give a residue, which was purified by silica gel flash chromatography (5% MeOH-0.5% NH3♦H2O-94.5% CH2Cl2) to afford the title compound as a solid (1.5 g). 13C NMR (CDCl3, 100 MHz) ) δ: 156.5, 131.4, 128.1, 126.9, 120.8, 110.3, 69.6, 55.3, 53.8, 45.1, 41.7, and 35.6.

Provenance & Evidence