Trifluoroacetic acid → HCID 15884734, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-(tert-butoxycarbonyl)-2-(2-methoxyphenyl)-4-methoxypiperidine (864 mg, 2.67 mmol) in CH2Cl2 at 0° C. was added TFA (9.6 mL) and the resulting solution was stirred at 0-40° C. for 2 hours. TFA was removed in vacuo, and the residue was stirred with 40 mL of 1:1 mixture of CH2Cl2 and 1N NaOH for 20 minutes. The layers were separated and the aqueous layer was extracted with CH2Cl2 (3×15 ml). The combined organic layers were washed with brine, dried over MgSO4, and concentrated in vacuo to afford the title compound as a light brown oil (565 mg). 1H NMR (CDCl3, 400 MHz) δ:3.82 (3H, s, OMe), 3.37 (3H, s, OMe).

Provenance & Evidence