HCID 15884745, compound → HCID 15884740, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-glycyl-4-methoxy-1,2,3,4-tetrahydroisoquinoline in 25 mL of THF was cooled in an ice bath and 10 M solution of borane-methyl sulfide complex in THF (3.85 mL) was added dropwise. The resulting mixture was warmed to 55° C. and then to reflux for 4 hours. Excess borane was destroyed by addition of 6N HCl. The resulting mixture was heated to 100° C. for 1 hour. The resulting solution was first extracted with EtOAc and then with 10% iPrOH—CH2Cl2. The iPrOH—CH2Cl2 extract gave 880 mg (28%) of the title compound.

Provenance & Evidence