HCID 178510074, compound → HCID 178510041, compound

Participants

Reaction Steps

To a solution of 4-cyano-7-nitrobenzotriazole (120 mg, 0.63 mmol) in methanol (250 ml) was added 10% Pd/C (1.0 g). The mixture was flushed with argon, then hydrogen was bubbled through the solution for 10 min. and a hydrogen atmosphere was maintained at balloon pressure for 4 hrs. The reaction mixture was flushed with argon and 10% Pd/C (1.0 g) was additionally added and a hydrogen atmosphere was maintained at balloon pressure for 1 hr. The mixture was filtered through celite and the celite was washed with methanol. The solvent was evaporated and chromatography of the resulting solid on silica gel (5%MeOH/CH2Cl2) gave the desired product (95 mg, 94%). 1H NMR (CD3OD): δ7.58 (d, 1H), 6.53 (d, 1H).

Provenance & Evidence