Potassium Iodide → HCID 9864078, compound

Participants

Reaction Steps

Potassium iodide (few crystals), potassium carbonate (140 mg) and benzimidazole (100 mg) were added to a solution of 6-chloromethyl-3-methyl-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (170 mg) in dimethylformamide (5 ml). After 2 h the reaction mixture was diluted with ethyl acetate and washed with saturated sodium hydrogen carbonate solution thrice and with brine, then dried over magnesium sulfate and evaporated. Column chromatography of the residue eluting with isohexane:ethyl acetate (1:1 to 0:1) containing 1% Et3N gave the title compound (130 mg).

Provenance & Evidence