Thionyl Chloride → HCID 18366631, compound

HRID 379583Notes

Reaction equation

HRID 379583 reaction equation
S(Cl)([Cl:3])=O.O[CH2:6][C:7]1[S:22][C:10]2[N:11]([CH2:18][CH:19]([CH3:21])[CH3:20])[C:12](=[O:17])[N:13]([CH3:16])[C:14](=[O:15])[C:9]=2[C:8]=1[C:23]([N:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1)=[O:24]>ClCCl>[Cl:3][CH2:6][C:7]1[S:22][C:10]2[N:11]([CH2:18][CH:19]([CH3:21])[CH3:20])[C:12](=[O:17])[N:13]([CH3:16])[C:14](=[O:15])[C:9]=2[C:8]=1[C:23]([N:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1)=[O:24]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 18366607HCID 18366607, compound

Product 1

HCID 18366631HCID 18366631, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Thionyl chloride (0.046 ml) was added to a solution of 1-{[1,2,3,4-tetrahydro-6-(hydroxymethyl)-3-methyl-1-(2-methylpropyl)-2,4-dioxothieno[2,3-d]pyrimidin-5-yl]carbonyl }pyrrolidine (0.1 15 g) in anhydrous dichloromethane (5 ml) under nitrogen. After 1 hour, the mixture was evaporated. The residue was redissolved in ethyl acetate (25 ml), washed with saturated aqueous sodium bicarbonate solution, dried over anhydrous magnesium sulfate, filtered and evaporated to give the subtitle compound (0.11 g) as an oil.

Workup

  1. customthe mixture was evaporated
  2. dissolutionThe residue was redissolved in ethyl acetate (25 ml)
  3. washwashed with saturated aqueous sodium bicarbonate solution
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

Sources & evidence

ORD record
ord-5f4b79f441034d07a5506712aa37ee47
Source dataset
uspto-grants-2001_10
Patent number
US06300334B1

Reaction notes

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