Tetrahydrofuran → 3-Methyl-1-(2-methylpropyl)-6-[(pyridin-3-yl)carbonyl]-5-[(2-thienyl)thio]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Participants

Reaction Steps

Prepared according to the method described in Example 38 from sodium hydride (0.068 g), 2-mercaptothiophene (0.15 ml), dry tetrahydrofuran (60 ml) and 5-bromo-3-methyl-1-(2-methylpropyl)-6-[(pyridin-3-yl)carbonyl]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (0.60 g, Example 39) with stirring at room temperature for 18 hours. After work up, the residue was purified by column chromatography over silica eluting with ethyl acetate:isohexane (1:1) to give the title compound as a yellow solid (0.46 g).

Provenance & Evidence