2-Propanethiol → HCID 18366576, compound

Participants

Reaction Steps

Prepared according to the method described in Example 37 step d from 5-bromo-3-methyl-6-[(1-methyl-1H-benzimidazol-2-yl)carbonyl]-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (1.2 g), sodium hydride (0.12 g) and 2-propanethiol (0.26 ml) in dry tetrahydrofuran (150 ml) with stirring at room temperature for 19 hours. The residue was purified by flash silica chromatography eluting with a gradient of 20-50% ethyl acetate in isohexane to give the title compound as a yellow solid (0.92 g).

Provenance & Evidence