HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 6-(chloromethyl)-3-methyl-5-[(1-methylethyl)thio]-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 6-(hydroxymethyl)-3-methyl-5-[(1-methylethyl)thio]-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione | HCID 18366584 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-(chloromethyl)-3-methyl-5-[(1-methylethyl)thio]-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione | HCID 18366615 | — |
Reaction Steps
Thionyl chloride (145 μl) was added to 6-(hydroxymethyl)-3-methyl-5-[(1-methylethyl)thio]-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (0.45 g) in dry dichloromethane (20 ml) and the mixture was stirred for 24 hours. The solvent was evaporated to give the subtitle compound as a an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06300334B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-c7579460b23b4cb2b9bee22952e453e5 |
| Source note | uspto-grants-2001_10 |