Hydrogen chloride-ethyl acetate → HCID 9875138, compound

Participants

Reaction Steps

To a solution of 36 mg of 4-{4-[(tert-Butoxycarbonyl-methyl-amino)-acetoxy]-3,5-dimethyl-benzyl}-1-[(2R,3R)-3-[4-(4-cyano-phenyl)-thiazol-2-yl]-2-(2,5difluoro-phenyl)-2-hydroxy-butyl]-1H-[1,2,4]triazol-4-ium bromide in ethylacetate(2 ml) was added dropwise 4N HCl ethylacetate solution(1 mL) and the mixture was stirred at r.t. for 4 hrs. The precipitate was filtered and washed with diethylether to give 1-{(2R,3R) -3-[4-(4-cyano-phenyl)-thiazol-2-yl]-2-(2,5-difluoro-phenyl)-2-hydroxy-butyl}-4-(3,5-dimethyl-4-methylaminoacetoxy-benzyl)-1H-[1,2,4]triazol-4-ium bromide (24.5 mg, 74% as HCl salt and as white solid);

Provenance & Evidence