HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → HCID 86757480, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3,5-Dimethyl-4-hydroxybenzaldehyde | HCID 75222 | — |
| Reactant | Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- | HCID 83692 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86757480 | HCID 86757480 | — |
Reaction Steps
To a solution of 1.35 g of 3,5-dimethyl-4-hydroxybenzaldehyde, 1.73 g of N-(tert-butoxycarbonyl)sarcosine and 0.2 g of 4-(N,N-dimethylamino)pyridine in 20 ml of dichloromethane was added 1.9 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and stirring was continued for 2.5 h at room temperature. The mixture was diluted with ethyl acetate and was washed with 0.25N HCl. The organic layer was dried over anhydrous sodium sulfate and concentrated to obtain 4-(tert-butoxycarbonylmethylamino)acetoxy-3,5-dimethylbenzaldehyde (2.9 g) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06300353B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-7d0fdd23981441b6a380a7e9ab75ee1b |
| Source note | uspto-grants-2001_10 |