Hydrochloric Acid → HCID 70112306, compound

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Reaction Steps

A mixture of 167 mg of (2R,3R)-4-[4-(N-tert-butoxycarbonyl-N-methylaminoacetoxy)-3,5-dimethylbenzyl]-1-[3-[4-(4-cyanophenyl)thiazol-2-yl]-2-hydroxy-2-(2,4,5-trifluorophenyl)butyl]-1H-[1,2,4]triazol-4-ium bromide and 2 ml of 4N-HCl in ethyl acetate in 4 ml of ethyl acetate was stirred for 4 h at room temperature and filtered. The white solid was washed with ether and dried in vacuo to obtain 141 mg(92%) of 1-[(2R,3R)-3-[4-(4-cyanophenyl)thiazol-2-yl]-2-hydroxy-2-(2,4,5-trifluorophenyl)butyl]-4-(3,5-dimethyl-4-methylaminoacetoxybenzyl)-1H-[1,2,4]triazol-4-ium bromide hydrochloride.

Provenance & Evidence