Ethyl iodoacetate → 1-[3-(4-cyano-phenyl)-propionyl]-6-(N-ethoxycarbonylmethyl-2,2-diphenyl-ethylamino)-1,2,3,4-tetrahydro-quinoline

HRID 379678Notes

Reaction equation

HRID 379678 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([N:13]2[C:22]3[C:17](=[CH:18][C:19]([NH:23][CH2:24][CH:25]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)=[CH:20][CH:21]=3)[CH2:16][CH2:15][CH2:14]2)=[O:12])=[CH:5][CH:4]=1)#[N:2].I[CH2:39][C:40]([O:42][CH2:43][CH3:44])=[O:41]>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][C:11]([N:13]2[C:22]3[C:17](=[CH:18][C:19]([N:23]([CH2:24][CH:25]([C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)[C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=4)[CH2:39][C:40]([O:42][CH2:43][CH3:44])=[O:41])=[CH:20][CH:21]=3)[CH2:16][CH2:15][CH2:14]2)=[O:12])=[CH:7][CH:8]=1)#[N:2]

Participants

3

Reactant 2

HCID 12183Ethyl iodoacetateHCID 183670031-[3-(4-Cyano-phenyl)-propionyl]-6-(2,2-diphenyl-ethylamino)-1,2,3,4-tetrahydro-quinoline

Product 1

HCID 183667971-[3-(4-cyano-phenyl)-propionyl]-6-(N-ethoxycarbonylmethyl-2,2-diphenyl-ethylamino)-1,2,3,4-tetrahydro-quinoline

Procedure

Prepared from 1-[3-(4-cyano-phenyl)-propionyl]-6-(2,2-diphenyl-ethylamino)-1,2,3,4-tetrahydro-quinoline (see Example 14(4)) and ethyl iodoacetate

Sources & evidence

ORD record
ord-ff6137c33f334d3cacc75dd09a9d8ae2
Source dataset
uspto-grants-2001_10
Patent number
US06300342B1

Reaction notes

Loading…