2,6-Dimethoxybenzoyl chloride → HCID 9909405, compound

Participants

Reaction Steps

N,N-diethyl-2-(4-aminophenoxy)ethylamine (4.00 g) was added into 2,6-dimethoxybenzoic acid chloride (4.20 g) in pyridine (40 ml) in an ice bath. After stirred for one hour at room temperature, the reaction mixture was concentrated under vacuum and residue was dissolved into chloroform (50 ml). The solution was washed with 1N sodium hydroxide aqueous solution followed by water and then saturated sodium chloride (50 ml, each). Solvent was distilled out and residue was purified by silica-gel column chromatography (chloroform:methanol=25:1) to obtain 4′-[2-(diethylamino)ethoxy]-2,6-dimethoxybenzanilide (5.01 g) as color-less crystal.

Provenance & Evidence