4-Toluenesulfonyl chloride → HCID 18368356, compound

Participants

Reaction Steps

4′-(2-Hydroxyethoxy)-3,4,5,6-tetrahydro-2H-pyran-4-carboxanilide (5.7 g) solution in pyridine (50 ml) was added with p-toluenesulfonylchloride (4.92 g). The mixture was stirred for 6 hours at room temperature and allowed to stand for one night. The reaction mixture was concentrated under vacuum and dissolved into chloroform (50 ml). This solution was washed water (50 ml) two times. After concentrated under vacuum, the organic layer was added with methanol (50 ml) and mixed. Crystals formed were collected by filtration, washed with water and then dried under vacuum at 60° C. to obtain 4′-[2-(p-toluenesulfonyloxy)ethoxy]-3,4,5,6-tetrahydro-2H-pyran-4-carboxanilide (5.17 g) as yellowish crystal.

Provenance & Evidence