HCID 15551259, compound → HCID 18368320, compound

HRID 379706Notes

Reaction equation

HRID 379706 reaction equation
[CH2:1]([NH:3][CH2:4][CH2:5][O:6][C:7]1[CH:21]=[CH:20][C:10]([NH:11][C:12]([CH:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[O:13])=[CH:9][CH:8]=1)[CH3:2].[ClH:22].C(O)C>CO>[ClH:22].[CH2:1]([NH:3][CH2:4][CH2:5][O:6][C:7]1[CH:21]=[CH:20][C:10]([NH:11][C:12]([CH:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[O:13])=[CH:9][CH:8]=1)[CH3:2]

Participants

4

Reactant 2

HCID 15551259HCID 15551259, compoundHCID 21887872Ethanol hydrochloride

Product 1

HCID 18368320HCID 18368320, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4′-[2-(Ethylamino)ethoxy]-3,4,5,6-tetrahydro-2H-pyran-4-carboxanilide (0.77 g) was suspended into methanol (5 ml) and 1N HCl/ethanol solution (3.95 ml) was added into this suspension. The compound dissolved completely and formed a uniform solution at once, but later on hydrochloride thereof was separated as crystals. Crystals were collected by filtration and washed with diethyl ether (10 ml), then dried under vacuum to obtain 4′-[2-(ethylamino)ethoxy]-3,4,5,6-tetrahydro-2H-pyran-4-carboxanilide hydrochloride (0.80 g) as white crystal.

Workup

  1. additionwas added into this suspension
  2. dissolutionThe compound dissolved completely
  3. customformed a uniform solution at once, but later on hydrochloride
  4. customthereof was separated as crystals
  5. filtrationCrystals were collected by filtration
  6. washwashed with diethyl ether (10 ml)
  7. customdried under vacuum

Sources & evidence

ORD record
ord-73b1805b5a614b708e596790419d7db4
Source dataset
uspto-grants-2001_10
Patent number
US06300368B1

Reaction notes

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