HCID 15551260, compound → HCID 18368334, compound

HRID 379715Notes

Reaction equation

HRID 379715 reaction equation
[CH:1]([NH:4][CH2:5][CH2:6][O:7][C:8]1[CH:26]=[CH:25][C:11]([NH:12][C:13](=[O:24])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[S:20]([CH3:23])(=[O:22])=[O:21])=[CH:10][C:9]=1[NH:27][S:28]([CH3:31])(=[O:30])=[O:29])([CH3:3])[CH3:2].[ClH:32].C(O)C>C(O)C>[ClH:32].[CH:1]([NH:4][CH2:5][CH2:6][O:7][C:8]1[CH:26]=[CH:25][C:11]([NH:12][C:13](=[O:24])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[S:20]([CH3:23])(=[O:21])=[O:22])=[CH:10][C:9]=1[NH:27][S:28]([CH3:31])(=[O:30])=[O:29])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 15551260HCID 15551260, compoundHCID 21887872Ethanol hydrochloride

Product 1

HCID 18368334HCID 18368334, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4′-[2-(Isopropylamino)ethoxy]-3′-methanesulfonamido-2-(methanesulfonyl)benzanilide (1.6 g) was dissolved into ethanol (50 ml) and to this solution 1N HCl/ethanol (9 ml) was added in an ice bath. The mixture was stirred. Crystals separated were collected by filtration, washed with ethanol (5 ml) and dried under vacuum to obtain 4′-[2-(isopropylamino)ethoxy]-3′-methanesulfonamido-2-(methanesulfonyl)benzanilide hydrochloride (1.6 g) as white crystal.

Workup

  1. additionwas added in an ice bath
  2. customCrystals separated
  3. filtrationwere collected by filtration
  4. washwashed with ethanol (5 ml)
  5. customdried under vacuum

Sources & evidence

ORD record
ord-ad45fd359ad14ef084cbf97a02934c3b
Source dataset
uspto-grants-2001_10
Patent number
US06300368B1

Reaction notes

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