Methoxyacetyl chloride → 6-Chloro-3-(methoxyacetylamino)-2-(3-methylbenzoyl)indole

HRID 379735Notes

Reaction equation

HRID 379735 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:20])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[CH:14]=1.[CH3:21][O:22][CH2:23][C:24](Cl)=[O:25]>>[Cl:11][C:7]1[CH:6]=[C:5]2[C:10]([C:2]([NH:1][C:24](=[O:25])[CH2:23][O:22][CH3:21])=[C:3]([C:12](=[O:20])[C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[CH:14]=3)[NH:4]2)=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 96623Methoxyacetyl chlorideHCID 183678773-Amino-6-chloro-2-(3-methylbenzoyl)-1H-indole

Product 1

HCID 183677526-Chloro-3-(methoxyacetylamino)-2-(3-methylbenzoyl)indole

Procedure

The title compound was prepared according to the procedure described in Example 19 employing 3-amino-6-chloro-2-(3-methylbenzoyl)indole (Example 21) and methoxyacetyl chloride. m.p.: 155-157° C.

Sources & evidence

ORD record
ord-a3864df9922d4a18bd1fac0b0e134c4b
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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