Propionyl chloride → HCID 18367965, compound

HRID 379739Notes

Reaction equation

[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:20])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=1.[C:21](Cl)(=[O:24])[CH2:22][CH3:23]>>[Cl:11][C:7]1[CH:6]=[C:5]2[C:10]([C:2]([NH:1][C:21](=[O:24])[CH2:22][CH3:23])=[C:3]([C:12](=[O:20])[C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=3)[NH:4]2)=[CH:9][CH:8]=1

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 18368029HCID 18368029, compound

Product 1

HCID 18367965HCID 18367965, compound

Procedure

The title compound was prepared according to the procedure described in Example 19 employing 3-amino-6-chloro-2-(3-chlorobenzoyl)indole (Example 30) and propionyl chloride. m.p.: 129-130° C. 1H-NMR (CDCl3): 9.95 (1H, br s), 8.30 (1H, d, J=9.2 Hz), 8.17 (1H, br s), 7.78-7.59 (3H, m), 7.51 (1H, t, J=7.7 Hz), 7.32 (1H, d, J=1.1 Hz), 7.11 (1H, dd, J=1.8, 8.8 Hz), 4.48 (2H, q, J=7.6 Hz), 1.30 (3H, t, J=7.6 Hz)

Sources & evidence

ORD record: ord-2872055831904a589a6aa7a05ad72c90
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06300363B1

Reaction notes

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