HCID 18368135, compound → HCID 18368034, compound

Participants

Reaction Steps

3-Acetylamino-2-(3-benzyloxybenzoyl)-6-chloroindole (Example 44, 0.42 g, 1.0 mmol) was hydrogenolyzed in the presence of palladium on activated carbon (10%, 0.10 g) in a mixture of ethyl acetate (10 ml) and ethanol (1.0 ml) at atmospheric pressure overnight. The mixture was filtered and the filtrate was concentrated in vacuo. The residual solid was recrystallization from ethyl acetate/hexane to afford 0.13 g (40%) of the title compound as a pale yellow solid. m.p.: 130-145° C. 1H-NMR (CDCl3) δ: 11.73 (1H, brs), 9.80-9.65 (2H, m), 7.62 (1H, d, J=8.4 Hz), 7.50-6.98 (5H, m), 1.76 (3H, s) The signal due to H of OH was not observed.

Provenance & Evidence