Isovaleryl chloride → HCID 17872807, compound

HRID 379753Notes

Reaction equation

[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:23])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=1.[C:24](Cl)(=[O:29])[CH2:25][CH:26]([CH3:28])[CH3:27]>>[Cl:11][C:7]1[CH:6]=[C:5]2[C:10]([C:2]([NH:1][C:24](=[O:29])[CH2:25][CH:26]([CH3:28])[CH3:27])=[C:3]([C:12](=[O:23])[C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)[NH:4]2)=[CH:9][CH:8]=1

Participants

Reactant 2

HCID 66054Isovaleryl chloride

HCID 18367923HCID 18367923, compound

Product 1

HCID 17872807HCID 17872807, compound

Procedure

The title compound was prepared according to the procedure described in Example 19 employing 3-amino-6-chloro-2-(3-trifluoromethylbenzoyl)indole (Example 49) and isovaleryl chloride. m.p.: 179-180° C.

Sources & evidence

ORD record: ord-f99a51e6fb5b4f57bfeb79b1537b76ab
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06300363B1

Reaction notes

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