HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(furan-2-yl)ethan-1-one → 3-Amino-6-chloro-1-(ethoxycarbonyl)-2-(2-furoyl)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(furan-2-yl)ethan-1-one | HCID 2795076 | — |
| Reactant | 4-Chloro-2-[(ethoxycarbonyl)amino]benzonitrile | HCID 18367888 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-Amino-6-chloro-1-(ethoxycarbonyl)-2-(2-furoyl)indole | HCID 18368094 | — |
Reaction Steps
The title compound was prepared according to the procedure described in step 2 of Example 1 from 4-chloro-2-(ethoxycarbonylamino)benzonitrile (Example 1, step 1) and 2-bromoacetylfuran (prepared according to the method of S. Kajigaeshi et al., Bull. Chem. Soc. Jpn., 1987, 60, 1159-1160). tlc: Rf=0.4 (33% ethyl acetate in hexanes)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06300363B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-7ee60dd310d1434097dbe1ec17f15aa8 |
| Source note | uspto-grants-2001_10 |