Isovaleryl chloride → HCID 18367954, compound

HRID 379773Notes

Reaction equation

HRID 379773 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12]([C:14]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][N:15]=1)=[O:13].[C:22](Cl)(=[O:27])[CH2:23][CH:24]([CH3:26])[CH3:25]>C(OCC)(=O)C.CCCCCC>[Cl:11][C:7]1[CH:6]=[C:5]2[C:10]([C:2]([NH:1][C:22](=[O:27])[CH2:23][CH:24]([CH3:26])[CH3:25])=[C:3]([C:12]([C:14]3[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][N:15]=3)=[O:13])[NH:4]2)=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 66054Isovaleryl chlorideHCID 183680323-Amino-6-chloro-2-(4-methoxy-pyridine-2-carbonyl)indole

Product 1

HCID 18367954HCID 18367954, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound was prepared according to the procedure described in Example 19 employing 3-amino-6-chloro-2-(4-methoxy-pyridine-2-carbonyl)indole (Example 72) and isovaleryl chloride. m.p.: 162-163° C. (ethyl acetate/hexane)

Sources & evidence

ORD record
ord-37911c7000b74825b256059002028e78
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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