Acetyl chloride → HCID 18368050, compound

HRID 379776Notes

Reaction equation

[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:15])[CH2:13][CH3:14].[C:16](Cl)(=[O:18])[CH3:17]>>[C:16]([NH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:15])[CH2:13][CH3:14])(=[O:18])[CH3:17]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 18367934HCID 18367934, compound

Product 1

HCID 18368050HCID 18368050, compound

Procedure

The title compound was prepared according to the procedure described in Example 19 employing 3-amino-6-chloro-2-propionylindole (Example 87) and acetyl chloride. m.p.: >270° C. 1H-NMR (DMSO-d6) δ: 11.72 (1H, br s), 9.93 (1H, br s), 7.59 (1H, d, J=8.4 Hz), 7.43 (1H, s), 7.07 (1H, d, J=8.4 Hz), 2.94 (2H, q, J=7.0 Hz), 2.15 (3H, s), 1.09 (3H, t, J=7.0 Hz)

Sources & evidence

ORD record: ord-1b83e650db3d49f2ace50fa311d7d9f5
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06300363B1

Reaction notes

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