2-Methoxypropanoic acid → 2-Benzoyl-6-chloro-3-[(2-methoxypropionyl)amino]indole

HRID 379812Notes

Reaction equation

HRID 379812 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[CH3:20][O:21][CH:22]([CH3:26])[C:23](O)=[O:24]>C(OCC)(=O)C.CCCCCC>[C:12]([C:3]1[NH:4][C:5]2[C:10]([C:2]=1[NH:1][C:23](=[O:24])[CH:22]([O:21][CH3:20])[CH3:26])=[CH:9][CH:8]=[C:7]([Cl:11])[CH:6]=2)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 922092-Methoxypropanoic acidHCID 183679723-Amino-2-benzoyl-6-chloroindole

Product 1

HCID 183678922-Benzoyl-6-chloro-3-[(2-methoxypropionyl)amino]indole

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound was prepared according to the procedure described in Example 114 employing 3-amino-2-benzoyl-6-chloroindole (Example 1) and 2-methoxypropionic acid. m.p.: 169-171° C. (ethyl acetate/hexane)

Sources & evidence

ORD record
ord-72783045b49c4c6590d6a67acb724dca
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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