3-Amino-2-benzoyl-6-chloroindole → HCID 86757482, compound

HRID 379815Notes

Reaction equation

HRID 379815 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[CH3:20][CH2:21][C:22](O)=[S:23]>>[C:12]([C:3]1[NH:4][C:5]2[C:10]([C:2]=1[NH:1][C:22](=[S:23])[CH2:21][CH3:20])=[CH:9][CH:8]=[C:7]([Cl:11])[CH:6]=2)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 183679723-Amino-2-benzoyl-6-chloroindoleHCID 178460587HCID 178460587, compound

Product 1

HCID 86757482HCID 86757482, compound

Procedure

The title compound was prepared according to the procedure described in Example 114 employing 3-amino-2-benzoyl-6-chloroindole (Example 1) and methylthioacetic acid. m.p.: 63-70° C. 1H-NMR (CDCl3) δ: 10.78 (1H, br s), 8.42 (1H, br s), 8.16 (1H, d, J=9.2 Hz), 7.86-7.79 (2H, m), 7.68-7.53 (3H, m), 7.31 (1H, d, J=1.8 Hz), 7.12 (1H, dd, J=9.2, 1.8 Hz), 3.39 (2H, s), 2.23 (3H, s)

Sources & evidence

ORD record
ord-c76c55259e7f4989b375e6b7909e99e3
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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