Chloroacetyl chloride → 2-Benzoyl-6-chloro-3-chloroacetylamino-1-(ethoxycarbonyl)indole

HRID 379816Notes

Reaction equation

HRID 379816 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[N:4]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:3]=1[C:17](=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[Cl:25][CH2:26][C:27](Cl)=[O:28]>>[C:17]([C:3]1[N:4]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:5]2[C:10]([C:2]=1[NH:1][C:27](=[O:28])[CH2:26][Cl:25])=[CH:9][CH:8]=[C:7]([Cl:11])[CH:6]=2)(=[O:24])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 183678333-Amino-2-benzoyl-6-chloro-1-(ethoxycarbonyl)indole

Product 1

HCID 183679602-Benzoyl-6-chloro-3-chloroacetylamino-1-(ethoxycarbonyl)indole

Procedure

The titled compound was prepared according to the procedure described in step 1 of Example 2 (Method A) from 3-amino-2-benzoyl-6-chloro-1-(ethoxycarbonyl)indole (Example 1, step 2) and chloroacetyl chloride.

Sources & evidence

ORD record
ord-2652408210d24327a64ffec2aedc29f7
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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