HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 3-Acetylamino-6-chloro-2-(pyridine-2-carbonyl)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | 3-Amino-6-chloro-2-(pyridine-2-carbonyl)indole | HCID 18367864 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Acetylamino-6-chloro-2-(pyridine-2-carbonyl)indole | HCID 18367994 | — |
Reaction Steps
The title compound was prepared according to the procedure described in Example 19 employing 3-amino-6-chloro-2-(pyridine-2-carbonyl)indole (Example 125) and acetyl chloride. m.p.: 211-212° C. (ethanol) 1H-NMR (DMSO-d6) δ: 12.02 (1H, br s), 10.34 (1H, br s), 8.82 (1H, d, J=4.4 Hz), 8.15-8.07 (2H, m), 7.85 (1H, d, J=8.8 Hz), 7.75-7.70 (1H, m), 7.63 (1H, d, J=1.8 Hz), 7.07 (1H, dd, J=1.8, 8.8 Hz), 2.02 (3H, s) IR (KBr) ν: 3450, 1690, 1620, 1580, 1570, 1480, 1350, 1240, 1180, 1160, 1030, 760 cm−1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06300363B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-da86509d4eea4172ad8bdc9e347573af |
| Source note | uspto-grants-2001_10 |