Acetyl chloride → HCID 18367973, compound

HRID 379829Notes

Reaction equation

HRID 379829 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:21])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]#[N:20])[CH:14]=1.[C:22](Cl)(=[O:24])[CH3:23]>C(OCC)(=O)C.CCCCCC>[C:22]([NH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:21])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]#[N:20])[CH:14]=1)(=[O:24])[CH3:23]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 18367753HCID 18367753, compound

Product 1

HCID 18367973HCID 18367973, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound was prepared according to the procedure described in Example 19 employing 3-amino-6-chloro-2-(3-cyanobenzoyl)indole (Example 127) and acetyl chloride. m.p.: 185-187° C. (ethyl acetate/hexane) 1H-NMR (DMSO-d6) δ: 11.91 (1H, br s), 9.85 (1H, brs), 8.12-8.04 (2H, m), 8.03-7.95 (1H, m), 7.77-7.62 (2H, m), 7.46 (1H, d, J=1.8 Hz), 7.12 (1H, dd, J=1.8, 8.8 Hz), 1.64 (3H, s)

Sources & evidence

ORD record
ord-fae5e50a53764ecdaea00410a3ce672c
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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