HCID 18368059, compound → HCID 18368080, compound

HRID 379859Notes

Reaction equation

HRID 379859 reaction equation
[C:1]([NH:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:14][CH3:15])[CH:12]=2)[NH:7][C:6]=1[C:16](N(OC)C)=[O:17])(=[O:3])[CH3:2].[C:22]1([Mg]Br)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:1]([NH:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:14][CH3:15])[CH:12]=2)[NH:7][C:6]=1[C:16](=[O:17])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 18368059HCID 18368059, compoundHCID 178418255HCID 178418255, compound

Product 1

HCID 18368080HCID 18368080, compound

Procedure

The title compound was prepared in an analogous manner to the procedure described in step 3 of Example 125 employing 3-acetylamino-5-methoxy-2-(N-methoxy-N-methylamino)carbonyl indole (step 4) and phenylmagnesium bromide.

Sources & evidence

ORD record
ord-e60d77f8b29f4564b9940e2002d2c257
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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